Effect of remimazolam compared to propofol on blood pressure variability in the elderly

Effect of remimazolam compared to propofol on blood pressure variability during general anesthesia induction in elderly patients: A randomized single-blind controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1011230012

Enrollment

Registered

2023-06-21

Start date

2023-06-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension during general anesthesia induction

Interventions

Group A: At the time of general anesthesia induction, remimazolam is administered at 12 mg/kg/h until unconsciousness. Group B: At the time of general anesthesia induction, propofol is administered at

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. ASA P.S. 1 or 2 2. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Acute angle closure glaucoma 2. Myasthenia gravis 3. Allergy to propofol 4. Allergy to remimazolam 5. Revised Cardiac Risk Index >0 6. Sleep apnea syndrome 7. BMI greater than 35 8. Previous thoracoplasty 9. Previous pneumonectomy

Design outcomes

Primary

Measure	Time frame
The maximum change in mean blood pressure during general anesthesia induction	—

Secondary

Measure	Time frame
The percentage of mean blood pressure <60 mmHg during general anesthesia induction, The maximum change in heart rate during general anesthesia induction, The percentage of heart rate <45 bpm during general anesthesia induction	—

Contacts

Public ContactTakayuki Hojo

Hokkaido University Hospital

ta-hojo@den.hokudai.ac.jp+81-11-706-4336

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026