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Effect of nitrous oxide on low PI status

Effect of nitrous oxide inhalation on perfusion indices in peripheral hypoperfusion during general anesthesia: a single group intervention study - Effect of N2O inhalation on PI in peripheral hypoperfusion during general anesthesia: a single group intervention study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCT1011230007
Enrollment
30
Registered
2023-05-23
Start date
2023-05-23
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral hypoperfusion state Robot Surgical Procedures

Interventions

Administration of 50% nitrous oxide
nitric oxide

Sponsors

Chaki Tomohiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients undergoing robotic and endoscopic surgery under general anesthesia for a scheduled time of 4 hours or more (e.g., including abdominal surgery, pulmonary surgery, endoscopic otolaryngology surgery, etc.)

Exclusion criteria

Exclusion criteria: Patients with PI less than 1.5% immediately after induction of general anesthesia. Patients whose PI never fell below 1.5% intraoperatively. Patients with unstable pulse oximeter in the fingers due to gangrene, nail disease, etc. Patients with peripheral circulatory insufficiency in the extremities for PI measurement such as arteriosclerosis obliterans before surgery. Patients who have difficulty inserting various other monitors (esophageal/palm thermometers, arterial pressure lines). Patients who have suffered massive intraoperative bleeding and require not only temperature maintenance but also continued postoperative circulatory and respiratory management. When consent cannot be obtained from the patient. Patients who the anesthesiologist in charge judges that they are not suitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
PI values before nitrous oxide administration, 30 minutes after administration, and 30 minutes after the end of administration.

Secondary

MeasureTime frame
Central temperature (esophageal temperature), peripheral temperature (palm temperature), blood pressure, pulse rate, pre & post-load, cardiac output, oxygen saturation, and regional tissue oxygen saturation before nitrous oxide administration, 30 minutes after administration, and 30 minutes after the end of administration. Central temperature, peripheral temperature, blood pressure, pulse rate, pre & post-load, Cardiac output, oxygen saturation, and regional tissue oxygen saturation every 5 minutes from before nitrous oxide administration to 30 minutes after the end of nitrous oxide administration. Shivering after awakening. Incidence of adverse events in the first 24 hours after surgery (hypoxic events (SpO2<92%), ischemic heart disease, stroke, nausea and vomiting, and number of antiemetic medications used).

Contacts

Public ContactTomoki Hirahata

Department of Anesthesiology, Sapporo Medical University School of Medicine

tomoki.hirahata@gmail.com+81-11-611-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026