Measurement of the concentration of free remimazolam

Establishment of a method to measure the concentration of protein non-binding remimazolam

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-jRCT1011230004

Enrollment

Registered

2023-04-29

Start date

2023-04-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiocascular surgery

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Equal to or older than 20 years old Patients who receive cardiovascular surgery under cardiopulmonary bypass with remimazolam

Exclusion criteria

Exclusion criteria: Refusal to participate Emergent case Allergy against remimazolam Acute angle closure glaucoma Myasthenia gravis Hepatic failure (Child Pugh equal to or more than 2) Renal failure (sCre equal to or more than 2 mg/dL) Obesity (BMI equal to or more than 35 kg/m2) Deep hypothermic circulatory arrest Patients who are considered to be inappropriate to participate to the study

Design outcomes

Primary

Measure	Time frame
Concentration of free remimazolam	—

Secondary

Measure	Time frame
Concentration of total remimazolam, a metabolite of remimazolam (CNS7054), and albumin Protein binding ratio of remimazolam	—

Contacts

Public ContactYusuke Yoshikawa

Sapporo Medical University

y.yoshikawa@sapmed.ac.jp+81-11-688-9663

Outcome results