The preventive effect of nitrous oxide on postanesthetic shivering

The effect of nitrous oxide on prevention of postanesthetic shivering in upper open abdominal surgery: a double blinded randomized controlled study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCT1011210036

Enrollment

Registered

2021-09-28

Start date

2021-09-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic or hepatic tumor Pancreatic or hepatic tumor

Interventions

Inhalation of 50% nitrous oxide is performed from start of closing surgical incision to 5 minutes before discontinuation of anesthetic agent.

D009609

nitrous oxide

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who received general anesthesia combined with epidural anesthesia Patients who received Pancreaticoduodenectomy/Distal pancreatectomy or Hepatectomy

Exclusion criteria

Exclusion criteria: Patients who can not receive epidural anesthesia Patients with difficulty of core or peripheral temeperature probe placement

Design outcomes

Primary

Measure	Time frame
Incidence of postanesthetic shivering from just after emergence to 30 minutes after emergence.	—

Secondary

Measure	Time frame
Severity of postanesthetic shivering Heart rate, blood pressure, SpO2, Perfusion index during 30 minutes after emergence from anesthesia Adverse events during postoperative 24 hours	—

Contacts

Public ContactTomohiro Chaki

Sapporo Medical University School of Medicine Hospital

chakitomohiro0728@yahoo.co.jp+81-11-611-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026