pancreatic cancer, hepatic cancer, bladder cancer, colon cancer, gastric cancer pancreatic cancer, hepatic cancer, bladder cancer, colon cancer, gastric cancer
Conditions
Interventions
The patients will be randomly assigned to two groups: remimazolam and propofol. Random assignment will be performed using Mujinwari (URL: https://mujinwari.biz/users/login). Age, sex, BMI, and presenc
D046650
mean circulatory filling pressure propofol remimazolam
Sponsors
Tomohiro Chaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients scheduled to undergo standby surgery under general anesthesia in the operating room of Sapporo Medical University Hospital. (2) Patients scheduled to undergo open pancreaticoduodenectomy or liver resection surgery. (3) The patient is scheduled to undergo arterial pressure monitoring using an arterial line under general anesthesia. (4) Adults aged 20 years or older at the time of surgery. (5) The patient's preoperative condition should be ASA-PS (American Society of Anesthesiologists Physical Status) 1-2 and in good general condition.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to propofol or remimazolam (2) Patients who are allergic to propofol, remimazolam, midazolam, or flumazenil. (3) Patients who are allergic to propofol, remimazolam, midazolam, or flumazenil. (4) Patients with severe hepatic or renal dysfunction that may affect drug metabolism. (5) Patients with severe hepatic or renal dysfunction that may affect drug metabolism (5) Other patients who are judged inappropriate for participation in this study by the principal investigators and sub-investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in mean circulatory filling pressure before and after induction of general anesthesia and 30 minutes after induction of general anesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient background (age, gender, body weight, ASA PS, underlying diseases including hypertension, and presence of antihypertensive medication) Changes in heart rate (HR) before and 30 minutes after induction of general anesthesia Change in body blood pressure (NBP) before and 30 minutes after induction of general anesthesia Transcutaneous arterial blood oxygen saturation (SpO2) Changes in perfusion index (PI) before and 30 minutes after induction of general anesthesia Change in the single cardiac output coefficient (esSVI) before and 30 minutes after induction of general anesthesia Cardiac coefficient (esCCI) before and 30 minutes after induction of general anesthesia Depth of anesthesia bispectral index (BIS) at each measurement time point Total dose of remimazolam and propofol during induction of anesthesia Incidence of adverse events: severe hypotension, use of hypertensive drugs, bradycardia, cardiac arrest | — |
Contacts
Public ContactChaki Tomohiro
Sapporo Medical University
Outcome results
None listed