Study on the Relationship Between Pulmonary Vascular Structure and Pathophysiology Using CT Imaging and Biomarkers

Evaluation of Pulmonary Vascular Structure and Clinical Significance in Obstructive Lung Disease Using Imaging and Biomarkers - PVCI-OLD Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000062042

Enrollment

129

Registered

2026-06-24

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease (COPD), Non-COPD respiratory diseases including bronchial asthma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Gender: Both males and females 2) Age 40 years or older at the time of consent 3) Smoking history: Not specified (H28-031 included current smokers or those with smoking history as criteria, while H27-204 did not set criteria regarding smoking history; therefore, this study does not specify smoking history) 4) Participants who enrolled in either of the previous studies (H27-204, H28-031) with documented informed consent obtained voluntarily and not subsequently withdrawn

Exclusion criteria

Exclusion criteria: Among healthy controls, those who did not undergo chest CT imaging for diagnostic purposes in routine clinical practice

Design outcomes

Primary

Measure	Time frame
Association between pulmonary vascular structure indices extracted from chest CT images (vascular pruning index, TBV5, etc.) and physical activity indices evaluated by accelerometer (daily step count, exercise intensity, activity time, etc.) (analysis using data collected in previous studies)	—

Secondary

Measure	Time frame
1) Association between mucus plug indices evaluated from chest CT images (mucus plug score, distribution pattern, occupancy area, etc.) and physical activity indices 2) Association between structural and functional markers extracted from brain MRI (cortical thickness, hippocampal volume, FA, cerebral blood flow, etc.) and physical activity indices 3) Association between blood biomarkers (GDF-15, exosome-derived microRNA, proteins, etc.) and pulmonary vascular structure indices, physical activity indices 4) Comparison of pulmonary vascular structural abnormalities among disease groups (COPD patients, non-COPD respiratory disease patients) and healthy controls 5) Association between pulmonary vascular structure indices, mucus plug indices and clinical indicators (pulmonary function, inflammatory markers, etc.)	—

Measure

Time frame

1) Association between mucus plug indices evaluated from chest CT images (mucus plug score, distribution pattern, occupancy area, etc.) and physical activity indices 2) Association between structural and functional markers extracted from brain MRI (cortical thickness, hippocampal volume, FA, cerebral blood flow, etc.) and physical activity indices 3) Association between blood biomarkers (GDF-15, exosome-derived microRNA, proteins, etc.) and pulmonary vascular structure indices, physical activity indices 4) Comparison of pulmonary vascular structural abnormalities among disease groups (COPD patients, non-COPD respiratory disease patients) and healthy controls 5) Association between pulmonary vascular structure indices, mucus plug indices and clinical indicators (pulmonary function, inflammatory markers, etc.)

—

Countries

Japan

Contacts

Public ContactTsunahiko Hirano

Yamaguchi University Hospital Department of Respiratory Medicine and Infectious Diseases

tsuna@yamaguchi-u.ac.jp0836853123

Outcome results