Premenstrual Syndrome
Conditions
Interventions
Vitamin C supplementation
Placebo
Sponsors
Hiroshima University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Females aged 18 to 39 years. Regular menstrual cycles (25 to 38 days). Presence of premenstrual syndrome. Habitual breakfast consumption. No current use of vitamin C containing supplements. Availability to participate throughout the study period and attend scheduled laboratory visits. Ability to download and use the designated smartphone application.
Exclusion criteria
Exclusion criteria: Highly irregular daily schedules (including night-shift or rotating shift work). History of gynecological disorders (e.g., ovarian cysts, uterine fibroids, or reproductive malignancies). History of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder, anxiety disorders, or depression). Current use of sex hormone therapies or anti-hormonal treatments. Dietary restrictions or medical nutrition therapy. Regular use of sleep medications or sleep-promoting supplements. Allergy to any ingredients of the study supplement. Planned travel across time zones exceeding 2 hours during the study period. Deemed unsuitable for participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PMS scores before and after the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| DRSP scores, Objective assessment of sleep and physical activity, Basal body temperature, Dietary intake, High-sensitivity C-reactive protein (hs-CRP), Iron deficiency assessment, Urinary metabolites, Presenteeism, Anxiety and depressive symptoms | — |
Countries
Japan
Contacts
Public ContactYu Tahara
Hiroshima University Department of Public Health and Health Policy
Outcome results
None listed