Patients with unresectable advanced or recurrent gastric cancer scheduled to receive zolbetuximab-containing chemotherapy
Conditions
Interventions
None listed
Sponsors
National Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who have been histologically diagnosed with gastric cancer. 2) Patients whose gastric cancer tumor tissue is confirmed to be CLDN18.2-positive by additional testing, including those who have already been confirmed to be CLDN18.2-positive at another institution prior to referral. 3) Patients who are scheduled to receive, or may potentially receive, anticancer drug therapy using zolbetuximab at the participating institution. 4) Patients aged 18 years or older at the time of informed consent. 5) Patients from whom at least one tumor tissue sample and at least one non-tumor sample can be obtained from the following specimens: Tumor samples: Tumor tissue samples newly collected after consent for this study. Non-tumor samples: Non-tumor tissue samples newly collected for this study and/or peripheral blood samples. If newly collected samples are difficult to obtain or if archived samples are considered useful for analysis, the use of archived samples will be permitted. 6) Patients who have provided written informed consent before study registration after receiving a sufficient explanation of the study. 7) Patients may be enrolled even if they are participating in other clinical trials, including investigational new drug trials.
Exclusion criteria
Exclusion criteria: 1) Patients who are considered unsuitable for enrollment in this study by the attending physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comprehensive phosphoproteomic profiling | — |
Secondary
| Measure | Time frame |
|---|---|
| Comprehensive gene expression analysis Protein profiling of circulating extracellular vesicles in blood | — |
Countries
Japan
Contacts
Public ContactShotaro Yamaguchi
National Cancer Center Japan Department of Gastrointestinal Medical Oncology
Outcome results
None listed