Study on the effect of continuous ingestion of a material for 1-deoxy-D-mannose on the host microbiome (gut and vaginal) and urinary excretion dynamics

Study on the effect of continuous ingestion of a material for preventing urinary tract infection (1-deoxymannose) on the host microbiome (gut and vaginal) and urinary excretion dynamics - Effect of continuous 1-deoxymannose ingestion on microbiome and urinary excretion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061984

Enrollment

Registered

2026-06-24

Start date

2026-06-24

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Duration: 29 days (1 day of pre-ingestion evaluation + 27 days of continuous ingestion + 1 day of post-ingestion evaluation) Test materials: 1-deoxy-D-mannose Dose: 1.0 g Administration: Take once

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Healthy Japanese female adults

Exclusion criteria

Exclusion criteria: The exclusion criteria are a history of diabetes mellitus, abnormal glucose metabolism, respiratory disease, chronic gastrointestinal disease, abnormal bowel movements, food allergies, urinary tract infection, or cystitis. Those with a BMI of 25.0 or higher. Those who routinely consume non-digestible and absorbable saccharides such as dietary fiber, or pharmaceuticals (e.g., antibiotics). Those with extreme menstrual irregularity.

Design outcomes

Primary

Measure	Time frame
Changes in gut microbiome and vaginal microbiome before and after 4 weeks (28 days) of continuous 1-deoxy-D-mannose ingestion	—

Secondary

Measure	Time frame
Changes in urinary 1-deoxymannose excretion before and after 4 weeks (28 days) of continuous 1-deoxy-D-mannnose ingestion	—

Countries

Japan

Contacts

Public ContactKenichi Tanabe

Nakamura Gakuen University Faculty of Nutritional Sciences

tanabek@nakamura-u.ac.jp092-851-2598

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026