delirium
Conditions
Interventions
For patients scheduled for major cardiovascular surgery and ICU admission who provided informed consent, the following sequential interventions and evaluations will be performed: 1. [Screening] Pre
patients scoring 24 or higher will be enrolled. 2. [Preoperative Evaluation] On the morning after admission, a research-specific blood sample (approx. 70 mL) will be collected, and DRS-R98 and MMSE a
Sponsors
Saga University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients scheduled to undergo elective cardiovascular surgery at our hospital with confirmed subsequent admission to the Intensive Care Unit (ICU). Patients aged 70 years or older and under 80 years at the time of obtaining informed consent. Patients (or their legally authorized representatives) who provided written informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: Patients aged under 70 years or 80 years and older. Patients with cognitive decline, including dementia, defined as a Mini-Mental State Examination (MMSE) score of less than 24 at screening. Patients with a history of or current alcohol dependence. Patients with a history or complication of brain disorders, including encephalitis, encephalopathy, traumatic brain injury, or cerebral infarction. Other patients judged by their primary physician to be inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inocum / Metric: Incidence of delirium during hospitalization Functional metrics of induced microglia-like (iMG) cells generated from blood samples (phagocytic activity, Ca2+ dynamics, production of inflammation-related substances, and responsiveness to BDNF) Comprehensive RNA expression levels in iMG cells Timepoint: From admission to discharge (or at the onset and resolution of delirium) | — |
Secondary
| Measure | Time frame |
|---|---|
| Inocum / Metric: Objective measurement scores extracted using AI from non-invasive devices (AI video monitors, simplified EEG, and wrist-worn activity trackers) Clinical factors (predisposing, precipitating, and contributing factors evaluated at admission and at the onset of delirium) Sequential changes in iMG cell RNA expression at multiple timepoints (at admission, delirium onset, and delirium resolution) Timepoint: At admission, at the onset of delirium, and upon resolution of delirium | — |
Countries
Japan
Contacts
Public ContactTakumi Shiraishi
Saga University, Faculty of Medicine Department of Psychiatry
Outcome results
None listed