A Multicenter Observational Study on the Relationship between Severe Alcoholic Hepatitis and Alcohol-Metabolizing Gene Polymorphisms (ADH1B and ALDH2)

Verification of ADH1B and ALDH2 Gene Polymorphisms Affecting Severe Alcoholic Hepatitis: A Multicenter Study - SAH-GENE study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061896

Enrollment

Registered

2026-06-13

Start date

2026-04-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Alcoholic Hepatitis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 20 years or older hospitalized for alcohol-induced liver injury. Written informed consent obtained.

Exclusion criteria

Exclusion criteria: Patients who do not provide informed consent for genetic testing. Patients whose primary liver disease is attributed to other etiologies such as HBV, HCV, or autoimmune hepatitis.

Design outcomes

Primary

Measure	Time frame
Association between ADH1B low-activity / ALDH2 active genotype and the onset of severe alcoholic hepatitis (SAH)	—

Countries

Japan

Contacts

Public ContactTomoko Tadokoro

Kagawa University Faculty of Medicine Department of Gastroenterology and Neurology

tadokoro.tomoko@kagawa-u.ac.jp0878985111

Outcome results