Development of a New Evaluation Method to Remove Image Noise and Detect Heart Disease Accurately

Optimization of 99mTc-HMDP Myocardial Uptake Assessment Based on Quantitative SPECT Simulation: Proposal of a Correction Model for Heart-Bone Reciprocal Phenomenon and Background Variations - HMDP-MUA (99mTc-HMDP Myocardial Uptake Assessment)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061894

Enrollment

Registered

2026-06-15

Start date

2026-07-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac amyloidosis

Interventions

None listed

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Adult patients who underwent nuclear medicine examinations using 99mTc-HMDP.

Exclusion criteria

Exclusion criteria: Patients with significant image artifacts (e.g., severe patient motion) that hinder analysis. Patients with suspected non-specific uptake of bone-seeking tracers due to a history of acute myocardial infarction within the previous 6 months, severe active myocarditis, chest trauma, or prior chest radiation therapy.

Design outcomes

Primary

Measure	Time frame
The heart-to-contralateral lung (H/CL) ratio, the heart-to-whole-body (H/WB) ratio, and the standardized uptake value (SUV) of the background regions (lungs and blood pool)	—

Countries

Japan

Contacts

Public ContactHiroki Nosaka

Ibaraki Prefectural University of Health Sciences Department of Radiological Sciences

nosakahi@ipu.ac.jp029-888-4000

Outcome results