Sepsis
Conditions
Interventions
None listed
Sponsors
Saitama Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Adults aged 18 years or older. 2) Patients who are clinically suspected of having an infectious disease and are classified as an intermediate-risk group according to the National Early Warning Score 2 (NEWS2), defined as a total NEWS2 score of 5 points or higher or a score of 3 points in any single parameter. 3) Healthy controls are defined as individuals with no history of chronic diseases or malignancies, who are not currently receiving medical treatment on an outpatient basis, who do not smoke, and whose alcohol consumption is less than one serving of sake (approximately 180 mL) per day. Healthy volunteers will be recruited through posters displayed in Building 3 of the Faculty of Science, The University of Tokyo. 4) Patients or healthy controls from whom written informed consent for study participation has been obtained from the individual themselves or, when applicable, from their legally authorized representative.
Exclusion criteria
Exclusion criteria: 1) Patients presenting with trauma. 2)Individuals deemed inappropriate for inclusion in the study by the investigator for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association of Sepsis Severity With Neutrophil Morphological Changes and Histone Modifications, Including Citrullination, Methylation, and Acetylation | — |
Countries
Japan
Contacts
Public ContactYusuke Naito
Saitama Medical University Emergency Unit
Outcome results
None listed