Healthy subject
Conditions
Interventions
A.250 Hz presented to both ears (control, no beat) B.250-250.25 Hz (0.25 Hz binaural beats) The order of the conditions is (A, B).
The order of the conditions is (B, A).
Sponsors
University of Tsukuba
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants will be included based on the following all criteria. 1)Not having difficulty in filling out Japanese explanatory documents, consent forms, and survey forms 2)Being able to come to the examination room on the 5th floor of the Innovative Medical Research Institute, University of Tsukuba without disrupting their normal daily rhythm 3)Living a regular life between 21:00-1:00 bedtime and 6:00-9:00 wake-up 4)Having no sleep disorder currently being treated 5)Having no hearing impairment in daily life
Exclusion criteria
Exclusion criteria: Participants will be excluded from the experiment based on the following criteria. 1)Irregular lifestyle (Regular: sleep time between 9:00 p.m. and 1:00 a.m., wake time between 6:00 a.m. and 9:00 a.m.) 2)BMI less than 18.5 or greater than 25 3)Worked night shifts (after 10:00 p.m.) 3 months prior to the experiment 4)Travel across time zones with time difference of 3 hours or more, 3 months prior to the experiment 5)regular consumes alcohol (40g (2 cans of beer) or more twice a week or more) 6)Smoker habit 7)Consumes more than 300mg (5 cups of 150mL) of coffee per day 8)MEQ score of less than 30 (extreme evening type) or greater than 70 (extreme morning type) 9)Pittsburgh Sleep Quality Index score greater than 5.5 10)Cannot perceive the frequency difference of the binaural beats and feel uncomfortable when listening to the auditory stimulation samples of this experiment 11)Claustrophobic 12)Pregnancy or its possibility 13)Breastfeeding 14)Having a disease that may change suddenly or its history 15)Having been treated for psychiatric disorders or sleep disorders, and those who have symptoms that are currently being treated 16)Deemed inappropriate by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG power at 0.25 Hz | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)0.25 Hz power in respiration and heart rate 2)Power and its temporal changes at frequencies other than 0.25 Hz in EEG, respiration, and heart rate 3)Detection time of changes in EEG, respiration, and heart rate based on comparison with the silent baseline 4)Amplitude changes in alpha/theta waves 5)Subjective reports via questionnaires | — |
Countries
Japan
Contacts
Public ContactTakashi Abe
University of Tsukuba International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Re
Outcome results
None listed