Safety of conservative follow-up for asymptomatic Kommerell diverticulum

Longitudinal changes in Kommerell diverticulum during conservative follow-up - Longitudinal changes in Kommerell diverticulum during conservative follow-up

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061775

Enrollment

Registered

2026-06-03

Start date

2025-04-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kommerell&#39

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We identified all consecutive patients diagnosed with Kommerell's diverticulum associated with aberrant left subclavian artery associated with a right aortic arch on CT between 2015 and 2024. KD was defined as a focal saccular dilation at the origin of the aberrant left subclavian artery.

Exclusion criteria

Exclusion criteria: (1) neonatal KD resected during surgery for other congenital cardiac or aortic anomalies; (2) aneurysmal change at the origin of a previously ligated aberrant left subclavian artery; (3) incomplete clinical or imaging follow-up because of loss to follow-up; and (4) acute aortic dissection involving the descending thoracic aorta at the time of KD diagnosis.

Design outcomes

Primary

Measure	Time frame
The primary outcome in the conservatively managed cohort was the occurrence of KD-related adverse events during follow-up, including: (1) new KD-related symptoms (eg, hoarseness, dysphagia, or KD-attributable chest/back pain); (2) acute aortic syndromes involving the KD segment (aortic dissection or rupture); and (3) KD-related death . Secondary outcomes included (1) longitudinal changes in CT-based indices and normalized ratios; (2) delayed intervention after initial conservative management (timing and indication); and (3) early and midterm operative outcomes among patients who underwent intervention (operative mortality and major perioperative complications).	—

Measure

Time frame

The primary outcome in the conservatively managed cohort was the occurrence of KD-related adverse events during follow-up, including: (1) new KD-related symptoms (eg, hoarseness, dysphagia, or KD-attributable chest/back pain); (2) acute aortic syndromes involving the KD segment (aortic dissection or rupture); and (3) KD-related death . Secondary outcomes included (1) longitudinal changes in CT-based indices and normalized ratios; (2) delayed intervention after initial conservative management (timing and indication); and (3) early and midterm operative outcomes among patients who underwent intervention (operative mortality and major perioperative complications).

—

Countries

Japan

Contacts

Public ContactTakuro Makiura

Osaka Medical and Pharmaceutical University Department of Thoracic and Cardiovascular Surgery

takurou.makiura@ompu.ac.jp072-683-1221

Outcome results