The Effects of Local Anesthetics on the Proliferation and Multipotency of Synovial Stem Cells

The Effects of Local Anesthetics on the Proliferation and Multipotency of Synovial Stem Cells - Effects of Local Anesthetics on Synovial Mesenchymal Stem Cells

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061774

Enrollment

Registered

2026-06-02

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Administer a local anesthetic to the site prior to synovial fluid aspiration

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled to undergo total knee replacement surgery at the Department of Orthopedics, Institute of Science Tokyo Hospital due to osteoarthritis of the knee, starting from the date the research was approved

Exclusion criteria

Exclusion criteria: Individuals suspected of having an infection. Individuals deemed medically unsuitable for other reasons.

Design outcomes

Primary

Measure	Time frame
Cartilage Differentiation Assay	—

Secondary

Measure	Time frame
Live cell percentage after enzymatic treatment Cell yield and viability after approximately two weeks of culture Adipogenic potential Bone differentiation potential Surface antigen expression	—

Countries

Japan

Contacts

Public Contactadministrator Office

Institute of Science Tokyo Center for Stem Cell and Regenerative Medicine

saisei01.arm@tmd.ac.jp03-5803-4017

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026