A prospective cohort study of long-term predictors of PTSD-related symptoms among new recruits of the Japan Maritime Self-Defense Force

Gene-environment interaction in post-traumatic stress disorder among Japan Maritime Self-Defense Force personnel: a long-term cohort study - JMSDF PTSD-GxE Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061759

Enrollment

8000

Registered

2026-06-10

Start date

2026-07-29

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PTSD-related symptoms and stress-related mental health outcomes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. New recruits of the Japan Maritime Self-Defense Force who enter training units or equivalent settings approved for the implementation of this study during the study period. 2. Individuals who understand the study explanation and provide written informed consent to participate in the study. 3. Individuals who are able to complete the baseline questionnaire and select either "questionnaire only" or "questionnaire plus saliva sample collection using Oragene" as their mode of participation. 4. Individuals aged 18 years or older at enrollment.

Exclusion criteria

Exclusion criteria: 1. Individuals who do not provide consent to participate in the study or who withdraw consent. 2. Individuals who are judged to have difficulty completing the baseline questionnaire. Individuals who have difficulty providing a saliva sample will be excluded from saliva collection and salivary DNA-based analyses but may participate in the "questionnaire only" arm. 3. Individuals for whom procedures necessary for assigning a study ID or linking annual data cannot be implemented.

Design outcomes

Primary

Measure	Time frame
The primary outcome is PTSD-related symptoms assessed annually using the Impact of Event Scale-Revised (IES-R). The primary outcome measure is the IES-R total score. Longitudinal changes in the IES-R total score, PTSD high-risk status defined as an IES-R total score of 25 or higher, and the first occurrence of an IES-R total score of 25 or higher during follow-up will be evaluated.	—

Secondary

Measure	Time frame
Key secondary outcomes are psychological and physical stress responses and high-stress status assessed annually using the Brief Job Stress Questionnaire; alcohol use/problem drinking assessed at baseline using the Alcohol Use Disorders Identification Test (AUDIT); gambling behavior/problem gambling assessed at baseline using the Problem Gambling Severity Index (PGSI); suicide-related events, including suicidal ideation, suicide planning, and suicide attempt, assessed at baseline for lifetime and past-12-month occurrence; and physical health indicators obtained from periodic health examinations during follow-up.	—

Measure

Time frame

Key secondary outcomes are psychological and physical stress responses and high-stress status assessed annually using the Brief Job Stress Questionnaire; alcohol use/problem drinking assessed at baseline using the Alcohol Use Disorders Identification Test (AUDIT); gambling behavior/problem gambling assessed at baseline using the Problem Gambling Severity Index (PGSI); suicide-related events, including suicidal ideation, suicide planning, and suicide attempt, assessed at baseline for lifetime and past-12-month occurrence; and physical health indicators obtained from periodic health examinations during follow-up.

—

Countries

Japan

Contacts

Public ContactHiroyuki Toda

National Defense Medical College Department of Psychiatry

psychiatry@ndmc.ac.jp04-2995-1619

Outcome results