Risk Assessment of Delayed Bleeding After Gastric Endoscopic Submucosal Dissection in Patients Receiving Anticoagulants and Validation of the Supplemented Guidelines for Gastrointestinal Endoscopy in Patients Undergoing Antithrombotic Therapy: A Multicenter Observational Study

Risk Assessment of Delayed Bleeding After Gastric Endoscopic Submucosal Dissection in Patients Receiving Anticoagulants and Validation of the Supplemented Guidelines for Gastrointestinal Endoscopy in Patients Undergoing Antithrombotic Therapy: A Multicenter Observational Study - Risk Assessment of Delayed Bleeding After Gastric Endoscopic Submucosal Dissection in Patients Receiving Anticoagulants and Validation of the Supplemented Guidelines for Gastrointestinal Endoscopy in Patients Undergoing Antithrombotic Therapy: A Multicenter Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061720

Enrollment

1760

Registered

2026-05-28

Start date

2022-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early gastric cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age >20 years. 2. Underwent ESD for early gastric cancer according to the Japanese Gastric Cancer Treatment Guidelines. 3. Receiving anticoagulants (warfarin or DOACs). 4. Underwent ESD according to the JGES Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment or the supplementary edition.

Exclusion criteria

Exclusion criteria: 1. ESD discontinued due to complications (e.g., bleeding or perforation), technical difficulties, or conversion to surgical treatment. 2. Inability to complete follow-up for at least 28 days after ESD. 3. Additional photodynamic therapy (PDT) performed after ESD. 4. Histopathological evidence of invasion deeper than the muscularis propria. 5. Participation in another interventional study. 6. Refusal to allow use of clinical data.

Design outcomes

Primary

Measure	Time frame
Evaluation of delayed bleeding rates before and after publication of the supplementary guidelines in anticoagulant users undergoing gastric ESD.	—

Secondary

Measure	Time frame
Validation of the supplementary guidelines in anticoagulant users undergoing gastric ESD.	—

Countries

Japan

Contacts

Public ContactMasaki Murata

National Hospital Organization Kyoto Medical Center Department of Gastroenterology and Hepatology

mura05310531@gmail.com0756419161

Outcome results