Adult
Conditions
Interventions
Apply the test product (warming cream) to the knee for 4 weeks each in summer and winter.
Sponsors
Yamada Bee Company, Inc.
Research Center for Immunological Analysis, Inc.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Participants who feel knee pain, fatigue, or discomfort. 2) Japanese adult male and female. 3) Participants who understand and can comply with the rules and guidelines throughout the study period. 4) Participants who have provided written informed consent of their own free will after fully understanding the study details.
Exclusion criteria
Exclusion criteria: 1. Participants with pain due to gout or rheumatism. 2. Participants with neuropathic or traumatic knee pain. 3. Participants who have undergone or are currently in need of surgery on their knee. 4. Participants with a history of bone or joint-related illnesses such as fractures or sprains within the last 3 months. 5. Participants who are continuously using cosmetics, pharmaceuticals, or quasi-drugs that claim or emphasize efficacy similar to or related to the efficacy to being evaluated in this study. 6. Participants who have changed their regularly used body care products or started using new body care products within the last 4 weeks. 7. Participants who are currently receiving treatment (e.g., hormone replacement therapy, drug therapy, exercise therapy, diet therapy, acupuncture, massage, physical therapy, and other treatments) at a medical institution for the treatment or prevention of knee pain, or who are judged to be in a condition requiring treatment. 8. Participants with a history of alcohol or drug dependence. 9. Participants who have previously experienced skin allergic symptoms from cosmetics or warming products (pharmaceuticals, quasi-drugs, or cosmetics). 10. Participants who are pregnant, breastfeeding, or planning to become pregnant during the study period. 11. Participants who have participated in another clinical study (e.g., using cosmetics, foods, drugs, quasi-drugs, or medical devices) within the last 4 weeks prior to informed consent, or who plan to participate in another clinical study during the scheduled period of this study. 12. Participants who are judged to be inappropriate for participation in this study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee pain | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee stiffness, discomfort, and fatigue Usability questionnaire Perception of warming effect | — |
Countries
Japan
Contacts
Public ContactChizuru Fujikura
Yamada Bee Company, Inc. Yamada Bee Company group Institute for Beauty Science, R&D department
Outcome results
None listed