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Monocyte-Centric Inflammatory Endotypes in Coronary Microvascular Dysfunction: Distinct Associations with Structural and Functional Phenotypes

Monocyte-Centric Inflammatory Endotypes in Coronary Microvascular Dysfunction: Distinct Associations with Structural and Functional Phenotypes: A Retrospective Observational Study - Monocyte-Centric Inflammatory Endotypes in Coronary Microvascular Dysfunction: Distinct Associations with Structural and Functional Phenotypes: A Retrospective Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000061710
Enrollment
200
Registered
2026-05-27
Start date
2026-04-24
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina with Non-Obstructive Coronary Arteries

Interventions

None listed

Sponsors

Tsuchiura Kyodo General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who underwent coronary angiography, acetylcholine spasm provocation testing, and comprehensive coronary physiological assessment of the left anterior descending artery as part of the diagnostic evaluation for chest pain or angina symptoms associated with chronic coronary syndrome at Tsuchiura Kyodo General Hospital. Patients without functionally significant coronary artery stenosis, defined as FFR >0.80, are included.

Exclusion criteria

Exclusion criteria: Patients with acute coronary syndrome, those undergoing hemodialysis, those with incomplete physiological or laboratory data, and those with poor pressure waveform quality are excluded.

Design outcomes

Primary

MeasureTime frame
The primary outcome measure is the association between hematological inflammatory indices and ANOCA phenotypes, including structural CMD, functional CMD, isolated IMR elevation, vasospastic angina, and microvascular spasm. CMD endotypes are defined according to CFR and IMR, while vasospastic angina and microvascular spasm are diagnosed by acetylcholine provocation testing.

Countries

Japan

Contacts

Public ContactTakahiro Watanabe

Tsuchiura Kyodo General Hospital Department of Cardiovascular Medicine

twatanabe.cvm@gmail.com+81-29-830-3711

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026