Whether brain lactate, peripheral blood amino acids, and facial expression changes are involved in the decline of executive function induced by incremental exercise

Whether brain lactate, peripheral blood amino acids, and facial expression changes are involved in the decline of executive function induced by incremental exercise - Whether brain lactate, peripheral blood amino acids, and facial expression changes are involved in the decline of executive function induced by incremental exercise

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061645

Enrollment

Registered

2026-05-21

Start date

2026-05-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

ncremental exercise using a cycle ergometer. The workload is incremented by 15 W/min until the participant can no longer maintain the prescribed pedaling cadence (volitional exhaustion

typical duration 20 min). Heart rate and arterial oxygen saturation are continuously monitored during exercise, and a low-intensity cool down on the ergometer is performed immediately after. Seated re

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults aged 18 to 30 years who are students enrolled at Niigata University of Health and Welfare and who provide written informed consent. Participants must have no respiratory abnormalities and no contraindications to MRI examination (e.g., metallic implants, cardiac pacemakers, claustrophobia).

Exclusion criteria

Exclusion criteria: Individuals with a history of cardiovascular disease, orthopedic conditions requiring exercise restriction, neurological disorders, or any serious internal medical condition currently under treatment; and those who have been advised by a physician to restrict physical exercise.

Design outcomes

Primary

Measure	Time frame
Changes in lactate concentration in the dorsolateral prefrontal cortex (dlPFC) measured by proton magnetic resonance spectroscopy (1H-MRS) before and after incremental exercise, and changes in executive function (reaction time and accuracy on the Flanker task).	—

Countries

Japan

Contacts

Public ContactGenta Ochi

Niigata University of Health and Welfare Department of Health and Sports

ochi@nuhw.ac.jp025-257-4595

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026