Association of DNA methylation of inflammatory, anti-inflammatory, and longevity-related genes with complications and prognosis in patients with chronic kidney disease

Association of epigenetic alterations in inflammatory/anti-inflammatory cytokine and longevity-related genes with complications and prognosis in patients with chronic kidney disease - Association of epigenetic alterations with complications and prognosis in patients with chronic kidney disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061635

Enrollment

250

Registered

2026-05-22

Start date

2016-05-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hemodialysis Patients: Patients undergoing maintenance hemodialysis at Kawasaki Clinic, Ebara Clinic, Monnaka Kidney Clinic, Toyosu Kidney Clinic, Shibagaki Clinic Jiyugaoka, Shibagaki Clinic Togoshi, Shibagaki Clinic Kugahara, Nagahara Sanwa Clinic, and Yukigaya Sanwa Clinic. CKD Patients: Patients undergoing treatment at the Department of Nephrology, Showa Medical University Hospital, and the Department of Nephrology, Showa Medical University Koto Toyosu Hospital. Healthy Controls: Subjects recruited at the Showa Medical University Clinical Pharmacology Research Institute.

Exclusion criteria

Exclusion criteria: 1)Patients under 20 years of age 2)Patients unable to provide written informed consent 3)Patients with advanced cancer, active hepatitis, infectious diseases, or collagen diseases

Design outcomes

Primary

Measure	Time frame
Composite of fatal and non-fatal cardiovascular disease and mortality	—

Secondary

Measure	Time frame
1)nutritional disorders, 2)bone metabolism disorders, 3)anemia, and 4)the rate of renal disease progression.	—

Countries

Japan

Contacts

Public ContactHirokazu Honda

Showa Medical University Graduate School of Medicine Department of Nephrology

hondah@med.showa-u.ac.jp03-3784-8533

Outcome results