Establishment of an Evaluation Method for Muscle Oxygen Dynamics during the 2-Minute Walk Test

Establishment of an Evaluation Method for Muscle Oxygen Dynamics during the 2-Minute Walk Test - NIRS-2MWT Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061605

Enrollment

Registered

2026-05-20

Start date

2026-05-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson&#39

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Parkinson's disease: Patients with Parkinson's disease currently undergoing physiotherapy at Hyogo Prefectural Rehabilitation Nishi-Harima Hospital; those capable of walking and performing activities of daily living independently or with supervision; those who have provided written consent. Healthy elderly participants: Aged 65 years or older; with normal cognitive function (MMSE score of 24 or higher); independent in activities of daily living; and free from any cardiopulmonary, musculoskeletal, neuromuscular or malignant conditions that would impede a 2-minute walk test. Young healthy adults: Students at Takarazuka Medical University who have consented to participate in the study.

Exclusion criteria

Exclusion criteria: Individuals with other brain, musculoskeletal, cardiac, or respiratory conditions that affect walking / Individuals who cannot provide informed consent to participate in the study

Design outcomes

Primary

Measure	Time frame
Change in muscle oxygen saturation (SmO2) of the tibialis anterior and gastrocnemius measured by NIRS during the 2-minute walk test	—

Secondary

Measure	Time frame
1.Muscle aerobic capacity by NIRS during maximal isometric ankle dorsiflexion (oxygenated/deoxygenated hemoglobin dynamics) 2.Physical cost index (PCI) 3.Pulmonary function (VC, FEV1, FEV1%) 4.Grip strength (bilateral) 5.Maximum calf circumference (bilateral) 6.SPPB (Short Physical Performance Battery) 7.MMSE (cognitive screening) 8.Assessements For PD patients: H&Y staging, MDS-UPDRS (Parts I-IV), LEDD, Parkinson Fatigue Scale	—

Measure

Time frame

1.Muscle aerobic capacity by NIRS during maximal isometric ankle dorsiflexion (oxygenated/deoxygenated hemoglobin dynamics) 2.Physical cost index (PCI) 3.Pulmonary function (VC, FEV1, FEV1%) 4.Grip strength (bilateral) 5.Maximum calf circumference (bilateral) 6.SPPB (Short Physical Performance Battery) 7.MMSE (cognitive screening) 8.Assessements For PD patients: H&Y staging, MDS-UPDRS (Parts I-IV), LEDD, Parkinson Fatigue Scale

—

Countries

Japan

Contacts

Public ContactKohei Marumoto

Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima Department of Rehabilitation Medicine/ Neurology

k.maru5081@gmail.com+81-791-58-1050

Outcome results