A Single-Center Prospective Interventional Study Evaluating the Efficacy and Safety of Needle Radiofrequency-Based Regenerative Therapy for Male and Female Pattern Hair Loss

A Single-Center Clinical Study Evaluating the Efficacy and Safety of Needle Radiofrequency Treatment in Patients with Male Androgenetic Alopecia and Female Pattern Hair Loss - NRF-MAGA/FPHL Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061569

Enrollment

Registered

2026-05-14

Start date

2021-05-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Androgenetic Alopecia and Female Pattern Hair Loss

Interventions

Needle radiofrequency treatment using an non-insulated microneedle bipolar radiofrequency device will be applied to areas affected by hair loss on the scalp. Treatments will be performed five times at

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults diagnosed with androgenetic alopecia or female pattern hair loss Including patients with poor response to previous hair restoration treatments, defined as a decrease in QTES score after prior therapy Ability to provide written informed consent

Exclusion criteria

Exclusion criteria: Patients diagnosed with alopecia other than MAGA/FPHL. Patients with alopecia associated with collagen diseases, thyroid disorders, infections, or malignancies. Patients with scalp disorders affecting evaluation, including seborrheic dermatitis, tinea capitis, or atopic dermatitis. Any condition deemed inappropriate by the investigator.

Design outcomes

Primary

Measure	Time frame
Changes in hair shaft diameter parameters (Maximum hair Diameter and Terminal Hair %) before and 12 months after starting treatment	—

Secondary

Measure	Time frame
Changes in Quantitative Trichoscopic Evaluation System: QTES scores Changes in hair density and hair number per follicular unit (HN/FU) Clinical photographic assessment Frequency and severity of adverse events	—

Countries

Japan

Contacts

Public ContactAsami Ito

Advanced Medical Care Inc. Noage Dental Division

a-ito@amcare.co.jp0354130082

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026