Major depressive disorder
Conditions
Interventions
Electroacupuncture
Minimal acupuncture
Sponsors
Saitama Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Men and women aged 18 to 64 years. 2) Diagnosis of Major Depressive Disorder (MDD) based on the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, Text Revision (DSM-5-TR) and structured interview using the Mini-International Neuropsychiatric Interview (M.I.N.I.). 3) Hamilton Depression Rating Scale (HAM-D) score of 8 or higher. 4) Pain Visual Analogue Scale (VAS) score of 30 mm or higher.
Exclusion criteria
Exclusion criteria: 1) Comorbidity of other psychiatric disorders, such as schizophrenia or bipolar disorder. 2) History of cerebrovascular disease, malignant tumor, head injury, or neurodegenerative diseases such as Parkinson's disease. 3) Pregnant women, lactating women, or women of childbearing potential who may be pregnant. 4) Severe suicidal ideation. 5) Substance dependence or drug abuse. 6) Contraindications to electroacupuncture. 7) Previous experience of acupuncture treatment within the past month. 8) Individuals judged to be inappropriate for inclusion in the study by the principal investigator or sub-investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the mean change of Oxy-Hb concentration in the prefrontal cortex | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Oxy-Hb concentration in the prefrontal cortex and the number of words generated during the VFT Changes in pain intensity Changes in mood states Correlations between changes in Oxy-Hb concentration in the prefrontal cortex and clinical indicators | — |
Countries
Japan
Contacts
Public ContactYuto Matsuura
Saitama Medical University Hospital Department of Oriental Medicine
Outcome results
None listed