Efficacy and Safety of Flower-Only Catheter Strategy Using Pulsed Field Ablation in Patients with Persistent Atrial Fibrillation

FLower strategy Outcomes With pulsed-field Energy foR Atrial Fibrillation - FLOWER-AF Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061552

Enrollment

150

Registered

2026-05-20

Start date

2026-02-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persistent atrial fibrillation

Interventions

Conventional method (basket, flower, and olive configurations) Flower strategy (flower and olive configurations only)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing PFA for persistent atrial fibrillation

Exclusion criteria

Exclusion criteria: 1. Patients who have expressed refusal to participate in this study 2. Patients deemed inappropriate for participation by the attending physician 3. Patients on hemodialysis and patients with cardiomyopathy

Design outcomes

Primary

Measure	Time frame
Recurrence rate of atrial fibrillation at 6 to 12 months after treatment	—

Secondary

Measure	Time frame
Degree of hemolysis (changes in haptoglobin, free hemoglobin, direct bilirubin, LDH, creatinine, and hemoglobin levels before PFA, immediately after PFA, and on the following day)	—

Countries

Japan

Contacts

Public ContactSachiko Shimono

Steel Memorial Yawata Hospital Cardiovascular Center

matakemo@outlook.jp0936723176

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026