Genome-wide serum microRNA profiling before and after sleeve gastrectomy: a pilot study comparing metabolically healthy and metabolically unhealthy obesity

Genome-wide serum microRNA profiling before and after sleeve gastrectomy: a pilot study comparing metabolically healthy and metabolically unhealthy obesity - SG-miRNA Obesity Phenotype Pilot Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061543

Enrollment

Registered

2026-05-13

Start date

2020-08-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe obesity

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with morbid obesity at our institution between 08/2020and 03/2021 Patients aged 18 years or older Availability of relevant clinical information from medical records Informed consent (or opt-out) obtained from patients or their legal representatives

Exclusion criteria

Exclusion criteria: Cases with poor sample quality unsuitable for analysis Cases with insufficient clinical information Cases who declined participation (opted out) (Relevant comorbidities, e.g., concurrent malignancies, etc.)

Design outcomes

Primary

Measure	Time frame
Changes in serum microRNA expression profiles before and 3 months after sleeve gastrectomy, assessed by genome-wide Agilent SurePrint G3 Human miRNA microarray (8x60K)	—

Secondary

Measure	Time frame
Changes in HOMA-IR, fasting glucose, fasting insulin, HbA1c, CRP, BMI, and percentage total weight loss before and 3 months after sleeve gastrectomy	—

Countries

Japan

Contacts

Public ContactSusumu Inamine

Ohama Daiichi Hospital Center for Metabolic and Bariatric Surgery

i.ssm@mac.com0570-00-5171

Outcome results