Depletion of Anti-HLA Antibodies by Targeted HLA-Expressing Platelet Transfusion

Depletion of Anti-HLA Antibodies by Targeted HLA-Expressing Platelet Transfusion - Depletion of Anti-HLA Antibodies by Targeted HLA-Expressing Platelet Transfusion

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061499

Enrollment

Registered

2026-06-01

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hematologic diseases requiring allogeneic hematopoietic cell transplantation

Interventions

1. Preparation of Target HLA-Expressing Platelets If platelet products expressing the target HLA antigens are available from the Japanese Red Cross Society, those products will be used. If such produ

s anti-HLA antibody levels, body size, and clinical condition. 2. Procedures for Transfusion of Target HLA-Expressing Platelets and Hematopoietic Cell Transplantation Collected platelet products w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Eligibility for allogeneic hematopoietic cell transplantation at our institution 2. Presence of donor-specific anti-HLA antibodies (DSA) with an MFI of >=5,000 3. Availability of target HLA-expressing platelet products

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Changes in anti-HLA antibody levels (mean fluorescence index: MFI) before and after transfusion of target HLA-expressing platelets	—

Secondary

Measure	Time frame
1) Identification of anti-HLA antibody recognition sites by eplet analysis 2) Engraftment rate following transfusion of target HLA-expressing platelets 3) Evaluation of complications associated with transfusion of target HLA-expressing platelets	—

Countries

Japan

Contacts

Public ContactKazuhiro Ikegame

Aichi Medical University Hematopoietic cell transplantation center

kame@aichi-med-u.ac.jp+81-561-63-2086

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026