The effect of letrozole co-administration with follitropin delta on unexpected poor ovarian response and embryological/reproductive outcomes in high-AMH patients: a retrospective cohort study

The effect of letrozole co-administration with follitropin delta on unexpected poor ovarian response and embryological/reproductive outcomes in high-AMH patients: a retrospective cohort study - DeltAI 2 dtudy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061498

Enrollment

600

Registered

2026-05-08

Start date

2025-05-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: All patients who underwent follitropin delta GnRH antagonist stimulation cycles between November 2021 and April 2026

Exclusion criteria

Exclusion criteria: (i) oocyte retrieval was not performed due to complete ovulation prior to retrieval; (ii) transvaginal oocyte retrieval was not possible due to uterine fibroids causing inaccessibility of the ovary; or (iii) excessive oocyte retrieval with ovarian hyperstimulation requiring cycle cancellation. Patients with antiphospholipid syndrome or systemic lupus erythematosus were retained in the stimulation and embryological analyses but excluded from pregnancy outcome analyses

Design outcomes

Primary

Measure	Time frame
the rate of poor response	—

Secondary

Measure	Time frame
laboratory & pregnancy outcomes	—

Countries

Japan

Contacts

Public ContactHiromasa Kuroda

Haruki Ladies Clinic Gynecology

kuroda@haruki-cl.com0662818801

Outcome results