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Effects of AI-generated misinformation about the effectiveness of dietary supplements against hypertension on health beliefs and behavioral intentions

Effects of AI-generated misinformation about the effectiveness of dietary supplements against hypertension on health beliefs and behavioral intentions among the Japanese general public: a randomized controlled trial - AI Supplement Misinformation RCT (Hypertension)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000061491
Enrollment
800
Registered
2026-05-08
Start date
2026-03-10
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exposure to dietary supplement misinformation related to hypertension

Interventions

Participants in the intervention group view AI generated misinformation claiming that four dietary supplements.euglena, turmeric, probiotics, or oyster extract is effective for lowering blood pressure

Sponsors

The University of Tokyo
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Individuals aged 18 to 64 years Registered panel members of a Japanese survey company who are able to complete an online survey Individuals who have experience using generative AI Individuals who provide informed consent online

Exclusion criteria

Exclusion criteria: Individuals who are not aware of dietary supplements Individuals who have no experience using generative AI Health care professionals, including physicians, nurses, pharmacists, registered dietitians, and dietitians Individuals working in the AI field, including AI researchers or developers Individuals with a personal or household history of hypertension Individuals currently receiving dietary therapy under the guidance of health professionals Individuals who fail the attention-check question

Design outcomes

Primary

MeasureTime frame
Primary outcomes This study has four primary outcomes: Belief in the hypertension-related effectiveness of euglena supplements. Belief in the hypertension-related effectiveness of turmeric supplements. Belief in the hypertension-related effectiveness of lactic acid bacteria supplements. Belief in the hypertension-related effectiveness of oyster extract supplements. Each primary outcome is assessed using three items measuring the perceived effectiveness of the corresponding dietary supplement for: (1) lowering blood pressure, (2) heart and vascular health, and (3) preventing hypertension. Each item is rated on a 6-point Likert scale ranging from 1 = strongly disagree to 6 = strongly agree. For each dietary supplement, the mean of the three item scores is calculated to produce a separate supplement-specific primary outcome score. Higher scores indicate stronger beliefs in the hypertension-related effectiveness of the corresponding dietary supplement. All four primary outcomes are measured before and immediately after participants view the assigned misinformation or corrective-information messages. For each primary outcome, the mean score measured immediately after message exposure is the primary endpoint. The four supplement-specific outcomes are analyzed separately. No overall primary outcome score combining all 12 items is used.

Secondary

MeasureTime frame
Secondary outcomes include: 1) general beliefs about the health-promoting, disease-preventive, and disease-treatment effects of dietary supplements; 2) intentions to purchase or use dietary supplements for lowering blood pressure, maintaining heart and vascular health, or preventing hypertension; 3) intentions to share AI-generated information claiming that dietary supplements are effective against hypertension via social media or word of mouth; and 4) intentions to consult health professionals about dietary supplement use. Each item is rated on a 6-point Likert scale ranging from 1 = strongly disagree to 6 = strongly agree. Outcomes are measured before and immediately after viewing the intervention or control message.

Countries

Japan

Contacts

Public ContactMingxin Liu

Graduate School of Medicine, The University of Tokyo Department of Health Communication

liumingxin98@g.ecc.u-tokyo.ac.jp09062421998

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026