Healthy women
Conditions
Interventions
Participants will apply a cream containing rice bran-derived gamma-oryzanol to one side of the face twice daily (morning and evening) for 8 consecutive weeks. Assessments will be conducted on the chee
Sponsors
Tsuno Rice Fine Chemicals Co., Ltd.
Wakayama Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women between the ages of 30 and 60 at the time consent is obtained. 2. Healthy and free from chronic physical diseases, confirmed by medical interview. 3. The applicant must not be using any medicated cosmetics, supplements, or other products that are expected to have related efficacy. 4. Individuals who have received sufficient explanation regarding the purpose and content of this trial, possess the capacity to consent, voluntarily volunteer to participate after fully understanding the details, and can provide written consent to participate in this trial. 5. Individuals who can attend the designated examination date and undergo the examination. 6. Individuals deemed suitable for participation in this trial by the principal investigator.
Exclusion criteria
Exclusion criteria: 1. Who currently suffer from any disease and are under medication. 2. Who have been determined by the examining physician to have a serious skin condition such as dermatitis. 3. Who cannot intentionally refrain from being exposed to direct sunlight, such as sunburn, during the examination period. 4. Who show statistical outliers in measurements of primary and secondary endpoints. 5. Who have allergies (to pharmaceuticals or products related to the test materials). 6. Who is pregnant, lactating, or intends to become pregnant during the study period. 7. Who are currently, or have been within the past month at the time of consent, in the habit of continuously ingesting or applying a drug that relation to the area to be measured. 8. Who are otherwise deemed by the investigator to be inappropriate for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in sebum levels of the skin after application | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in transepidermal water loss (TEWL), skin hydration, skin viscoelasticity, melanin level, and erythema score after of application | — |
Countries
Japan
Contacts
Public ContactJingxiu Zhou
Tsuno Rice Fine Chemicals Co., Ltd. Section 1, Planning and Development Dept. 3, Research and Development Div.
Outcome results
None listed