Stroke
Conditions
Interventions
In addition to standard rehabilitation, multisensory stimulation (visual, auditory, olfactory, gustatory, tactile, kinesthetic, proprioceptive, and somatosensory) will be administered for 15 minutes p
from the following day onward, it will be provided twice daily (morning and afternoon), five days per week.
Standard rehabilitation will be administered.
Sponsors
Nagasaki University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients admitted to the Stroke Center of Nagasaki University Hospital between the date of institutional approval and March 31, 2028. 2.Patients who meet a Glasgow Coma Scale (GCS) score of 3 to 12 as assessed by a physician at admission. 3.Patients with supratentorial cerebral infarction. 4.Patients aged 18 years or older who have received a full explanation of the study and for whom written informed consent has been obtained from a legally authorized representative based on their free will and sufficient understanding.
Exclusion criteria
Exclusion criteria: 1.Patients with pre-existing disorders of consciousness (DOC) prior to admission. 2.Patients with an implanted cardiac device, such as a pacemaker. 3.Patients with hemodynamic instability. 4.Patients with a history of stroke or other neurological diseases. 5.Exclude individuals with a known allergy to citrus essential oils, those with a history of dermatitis or respiratory symptoms induced by essential oil use, and those with severe bronchial asthma. 6.Rehabilitation therapy exceeding 5 units per day during the multisensory stimulation intervention period. 7.Patients deemed inappropriate for participation in the study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the change in the total score of the Coma Recovery Scale-Revised (CRS-R) from hospital day 2 (baseline) to day 7. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include:Change in the CRS-R total score from baseline to day 7, Changes in CRS-R subscale scores, Changes in diagnostic category of consciousness, Changes in Japan Coma Scale (JCS), Glasgow Coma Scale (GCS), and National Institutes of Health Stroke Scale (NIHSS) scores from baseline to days 7 and 14, Occurrence of adverse events. | — |
Countries
Japan
Contacts
Public ContactYeonghee Lee
Nagasaki University Hospital Rehabilitation Department
Outcome results
None listed