Clinical Outcomes of Left Bundle Branch Area and BachmaNn BunDle Pacing: Multicenter ReAl-World Registry in Kanagawa (LANDMARK study)

Clinical Outcomes of Left Bundle Branch Area and BachmaNn BunDle Pacing: Multicenter ReAl-World Registry in Kanagawa (LANDMARK Study) - LANDMARK Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061421

Enrollment

2000

Registered

2026-06-02

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All patients undergoing pacemaker-related procedures at participating institutions will be included. Pacemaker therapy is defined as transvenous implantation of a conventional pacemaker, an implantable cardiac defibrillator (ICD), or cardiac resynchronization therapy (CRT) device

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients undergoing pacemaker-related procedures will be included. Pacemaker therapy is defined as transvenous implantation of a conventional pacemaker, an implantable cardiac defibrillator ICD, or cardiac resynchronization therapy CRT device.

Exclusion criteria

Exclusion criteria: Patients who underwent leadless pacemaker

Design outcomes

Primary

Measure	Time frame
The efficacy endpoints will include all-cause mortality, cardiac death, heart failure, and peri-procedural and late complications. The final analysis will be conducted after completion of the 5-year follow-up.	—

Secondary

Measure	Time frame
LBBAP Evaluation of short and long term outcomes based on baseline patient characteristics and the presence or absence of peri and post procedural complications Assessment of procedural success rate based on predefined success criteria Evaluation of the learning curve effect Impact of institutional operator volume on procedural success rates Comparative evaluation of hemodynamics and prognosis between LBBP and LVSP Assessment of lead durability Evaluation of efficacy in specific cardiomyopathies eg amyloidosis Assessment of peri procedural complication rates Evaluation of safety and efficacy in iatrogenic atrioventricular block Assessment of reduction in the incidence of supraventricular arrhythmias These outcomes will be compared with the non conduction system pacing non CSP cohort according to the study design Evaluation of the incidence and prognosis of pacing induced cardiomyopathy at 5 years in CSP versus non CSP cohorts BBP Evaluation of clinical outcomes according to atrial pacing site Assessment of procedural success rate of BBP Validation of success criteria for BBP Evaluation of the impact of reactive ATP and atrial pacing site on supraventricular tachyarrhythmias Assessment of the incidence and persistence of supraventricular arrhythmias according to pacing site ICD CRT Evaluation of the efficacy of LOT CRT in Japan Assessment of the efficacy of ATP delivered via SelectSecure leads in LOT CRTD Evaluation of efficacy in ischemic vs non ischemic cardiomyopathy and in left bundle branch block vs left ventricular conduction delay Assessment of the impact of BBP on the incidence of supraventricular arrhythmias in ICD patients These outcomes will be compared with conventional ICD CRT cohorts according to the study design	—

Measure

Time frame

LBBAP Evaluation of short and long term outcomes based on baseline patient characteristics and the presence or absence of peri and post procedural complications Assessment of procedural success rate based on predefined success criteria Evaluation of the learning curve effect Impact of institutional operator volume on procedural success rates Comparative evaluation of hemodynamics and prognosis between LBBP and LVSP Assessment of lead durability Evaluation of efficacy in specific cardiomyopathies eg amyloidosis Assessment of peri procedural complication rates Evaluation of safety and efficacy in iatrogenic atrioventricular block Assessment of reduction in the incidence of supraventricular arrhythmias These outcomes will be compared with the non conduction system pacing non CSP cohort according to the study design Evaluation of the incidence and prognosis of pacing induced cardiomyopathy at 5 years in CSP versus non CSP cohorts BBP Evaluation of clinical outcomes according to atrial pacing site Assessment of procedural success rate of BBP Validation of success criteria for BBP Evaluation of the impact of reactive ATP and atrial pacing site on supraventricular tachyarrhythmias Assessment of the incidence and persistence of supraventricular arrhythmias according to pacing site ICD CRT Evaluation of the efficacy of LOT CRT in Japan Assessment of the efficacy of ATP delivered via SelectSecure leads in LOT CRTD Evaluation of efficacy in ischemic vs non ischemic cardiomyopathy and in left bundle branch block vs left ventricular conduction delay Assessment of the impact of BBP on the incidence of supraventricular arrhythmias in ICD patients These outcomes will be compared with conventional ICD CRT cohorts according to the study design

—

Countries

Japan

Contacts

Public ContactNoriaki Moriyama

Shonan Kamakura General Hospital Cardiology

e2718nm@gmail.com0467461717

Outcome results