A study of cardiac amyloidosis 5 years after surgery in patients with amyloid deposition detected during carpal tunnel syndrome or trigger finger surgery

A study on the 5-year positivity rate of cardiac amyloidosis in patients with amyloid deposition detected during surgery for carpal tunnel syndrome or trigger finger who were negative for cardiac amyloidosis at the time of surgery - -year follow-up study of cardiac amyloidosis in amyloid-positive CTS/trigger finger surgical patients

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061345

Enrollment

250

Registered

2026-04-21

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carpal tunnel syndrome, trigger finger, amyloid deposition, cardiac amyloidosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent surgery for carpal tunnel syndrome or trigger finger at Saiseikai Yamaguchi General Hospital from February 2020 onward. Patients with amyloid deposition confirmed by pathological examination of tissue collected during surgery. Patients judged to be negative for cardiac amyloidosis at the time of surgery based on cardiovascular evaluation. Patients who can be contacted at the time of the 5-year follow-up evaluation. Patients from whom informed consent for participation in this study can be obtained

Exclusion criteria

Exclusion criteria: Patients who do not give their consent to participate in the study Patients for whom it is difficult to obtain the information required for the 5-year follow-up or to carry out the necessary tests Patients deemed unsuitable by the principal investigator

Design outcomes

Primary

Measure	Time frame
The rate of conversion to cardiac amyloidosis at the five-year follow-up assessment	—

Secondary

Measure	Time frame
1. Comparison of the positivity rate between cases of carpal tunnel syndrome and trigger finger 2. Association between positivity and clinical factors such as age, gender, bilateral involvement, involvement of multiple fingers, and spinal stenosis 3. Association between the location and subtype of amyloid deposits at the time of surgery and positivity at the 5-year follow-up 4. Echocardiographic findings, biomarkers, and distribution of 99mTc-PYP myocardial scintigraphy uptake at the 5-year follow-up	—

Measure

Time frame

1. Comparison of the positivity rate between cases of carpal tunnel syndrome and trigger finger 2. Association between positivity and clinical factors such as age, gender, bilateral involvement, involvement of multiple fingers, and spinal stenosis 3. Association between the location and subtype of amyloid deposits at the time of surgery and positivity at the 5-year follow-up 4. Echocardiographic findings, biomarkers, and distribution of 99mTc-PYP myocardial scintigraphy uptake at the 5-year follow-up

—

Countries

Japan

Contacts

Public ContactTeruyasu Ohno

Saiseikai Yamaguchi General Hospital Department of Orthopedic Surgery

teruyasu1970@icloud.com0839016111

Outcome results