Evaluation of Biological Age using Salivary HSP70 and its Association with Frailty

Evaluation of Biological Age using Salivary HSP70 and its Association with Frailty - Evaluation of Biological Age using Salivary HSP70 and its Association with Frailty

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061324

Enrollment

300

Registered

2026-04-20

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Adults

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Persons who received a sufficient explanation of the purpose and contents of the study, have the capacity to consent, applied with free will with sufficient understanding, and agreed to participate. 2. Japanese persons who are 18 years old or more at the time of consent. 3. Persons who can visit the measurement venue.

Exclusion criteria

Exclusion criteria: 1. Persons with currently treated malignant tumors, severe heart failure or respiratory disease, chronic kidney disease requiring dialysis, or serious autoimmune diseases. 2. Persons currently receiving systemic steroid administration or immunosuppressant treatment. 3. Persons with obvious paralysis due to sequelae of cerebrovascular disease or those with neurodegenerative diseases. 4. Persons for whom walking or grip strength measurement is physically difficult due to acute fractures or joint diseases. 5. Persons with significant salivary secretion disorders such as Sjogren's syndrome. 6. Persons who have participated in other studies within one month before the start of the study, or those who intend to participate in another study after consenting to this study. 7. Persons judged as inappropriate by the principal investigator. 8. Persons who are pregnant or breastfeeding.

Design outcomes

Primary

Measure	Time frame
Salivary HSP70 concentration at the time of examination (measured by ELISA).	—

Secondary

Measure	Time frame
The following items at the time of examination: 1. Saliva volume 2. Gait function (walking speed, gait balance) 3. Motor function (one-leg standing, chair stand test) 4. Grip strength 5. Body composition, Blood pressure, Height 6. Facial skin information (VISIA) 7. Frailty-related questionnaires (Basic, Checklist, 11-item check, Izumo scale, Oral frailty self-check, etc.)	—

Countries

Japan

Contacts

Public ContactTomoko Noguchi

Saishunkan Pharmaceutical Co., Ltd. Research and Development Department

tomoko.matsuda@saishunkan.co.jp0962894444

Outcome results