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A prospective multicenter observational study investigating the association between the improvement rate of preoperative anemia and treatment outcomes in colorectal cancer

A prospective multicenter observational study investigating the association between the improvement rate of preoperative anemia and treatment outcomes in colorectal cancer - IRON study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000061318
Enrollment
200
Registered
2026-04-20
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

None listed

Sponsors

Yokohama City University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with histologically confirmed colorectal cancer Patients scheduled for primary tumor resection Patients whose hemoglobin level at the initial visit meets the following criteria: Male: < 13.0 g/dL Female: < 12.0 g/dL

Exclusion criteria

Exclusion criteria: Patients undergoing emergency surgery with primary tumor resection Patients with severe anemia requiring blood transfusion at the initial visit Patients with contraindications to iron therapy (e.g., hepatic or renal dysfunction, myelodysplastic syndromes [MDS], hemochromatosis, thalassemia, hemolytic anemia) Patients who have already received preoperative anemia treatment (blood transfusion within 1 month or erythropoietin use within 3 months) Patients deemed unsuitable for participation in this study by the principal investigator

Design outcomes

Primary

MeasureTime frame
Increase in hemoglobin (Hb): the change in Hb level from the start of treatment to the time of surgery.

Secondary

MeasureTime frame
Perioperative blood transfusion volume Incidence of perioperative complications Changes in laboratory values (ferritin, transferrin saturation [TSAT], and C-reactive protein [CRP])

Countries

Japan

Contacts

Public ContactSuguru Nukada

Yokohama City University Medical Center Department of Gastroenterological Surgery, Gastroenterological Center

nukada.sug.df@yokohama-cu.ac.jp045-261-5656

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026