Effects of a toothpaste containing beta-glucan on oral bacteria count

Evaluation of the inhibitory effect of beta-glucan-containing dentifrice on cariogenic bacteria: A clinical study - BG-Dentifrice Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061294

Enrollment

Registered

2026-05-01

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries

Interventions

beta-glucan-containing toothpaste group: Subjects will perform routine toothbrushing with the co-developed toothpaste containing beta-glucan for routine toothbrushing twice daily for 1 week. Control t

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male or female adults aged 18 years or older at the time of informed consent. 2. Subjects with clinically healthy gingiva. 3. Subjects who understand the study purpose and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Subjects with dental caries (excluding teeth requiring observation), gingivitis, or periodontitis. 2. Subjects who have taken antibiotics or anti-inflammatory drugs within the past month. 3. Current smokers. 4. Subjects currently undergoing dental treatment. 5. Regular users of electric toothbrushes. 6. Other individuals judged to be inappropriate for participation by the investigator.

Design outcomes

Primary

Measure	Time frame
1. Counts of mutans streptococci and Lactobacillus species in saliva 2. Total number of salivary cariogenic bacteria	—

Countries

Japan

Contacts

Public ContactWataru Ariyoshi

Kyushu Dental University Division of Infections and Molecular Biology, Department of Advanced Pathophysiological Science

arikichi@kyu-dent.ac.jp093-285-3052

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026