Healthy
Conditions
Interventions
Oral administration of a silicon-containing supplement according to a predefined stepwise algorithm. All participants receive 300 mg at the first administration and 100 mg at the second administration
Sponsors
Hiroshima University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy
Exclusion criteria
Exclusion criteria: 1) Individuals currently taking medicines and/or dietary supplements 2) Individuals with food allergies 3) Individuals currently participating in another clinical study, or who have participated in another clinical study within the past 3 months 4) Individuals who are pregnant, may be pregnant, or are breastfeeding 5) Individuals judged by the principal investigator or sub-investigator to be ineligible for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in exhaled hydrogen concentration from baseline during 0-8 h following oral administration of a silicon-containing supplement | — |
Secondary
| Measure | Time frame |
|---|---|
| - Cmax and AUC of the increase in exhaled hydrogen concentration from baseline during 0-8 h following oral administration of a silicon-containing supplement - Association between gut microbiome profiles and exhaled hydrogen and methane concentrations following oral administration of a silicon-containing supplement | — |
Countries
Japan
Contacts
Public ContactFumiko Higashikawa
Hiroshima University Hospital Medical Center for Translational and Clinical Research
Outcome results
None listed