Efficacy of Oral Care with MA-T in Preventing Ventilator-Associated Pneumonia in Intubated ICU Patients

Efficacy of Oral Care with On-Demand Generated Chlorous Acid Ion Solution (MA-T) in Preventing Ventilator-Associated Pneumonia in Intubated ICU Patients: A Single-Center, Open-Label, Non-Randomized Controlled Trial - MOUTH-CLEAN study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061190

Enrollment

200

Registered

2026-04-07

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubated patients in the intensive care unit

Interventions

Oral care with conventional oral care kit mouthwash (6 ml) and mouth paste (2 g) for brushing. Oral care using MA-T mouthwash (6 ml) and MA-T oral gel (2 g) for brushing, in place of conventional mout

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients intubated and receiving mechanical ventilation

Exclusion criteria

Exclusion criteria: Patients extubated within 48 hours of intubation Patients with oral or facial trauma Patients at risk of oral bleeding due to coagulopathy, oral ulcers, or other conditions that may be exacerbated by frequent oral care Patients capable of performing oral care independently Patients with pneumonia as the primary diagnosis at admission

Design outcomes

Primary

Measure	Time frame
Ventilator-Associated Pneumonia	—

Countries

Japan

Contacts

Public ContactMomoko Sugimoto

Tokyo Science University Hospital Trauma and Acute Critical Care Center

momoko.sugi@gmail.com03-3813-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026