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Elucidation of the Molecular Basis of Life-to-Death Transition: A Prospective Observational Study to Identify Biological Responses of Life Maintenance and Revitalization

Elucidation of the Molecular Basis of Life-to-Death Transition: A Prospective Observational Study to Identify Biological Responses of Life Maintenance and Revitalization - X-Life Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000061178
Enrollment
200
Registered
2026-04-07
Start date
2026-04-17
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart disease, Kidney disease, Malignant neoplasm, and Infectious disease

Interventions

None listed

Sponsors

Nara medical university hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients currently hospitalized at the Department of Cardiology/Nephrology, Nara Medical University Hospital, Nanwa Hospital, or Nishinokyo Hospital who have a medical history of any of the following conditions. Acute death model: Patients with severe acute heart failure, cardiogenic shock, fatal arrhythmia requiring mechanical circulatory support, or those in the terminal stage due to the progression of irreversible and fatal diseases. Slow death model: High-risk patients undergoing maintenance dialysis, patients requiring emergency initiation of dialysis, patients with chronic kidney disease complicated by severe infection, or patients with end-stage kidney disease who have opted for conservative kidney management.

Exclusion criteria

Exclusion criteria: Patients judged by the investigator to be unsuitable as subjects.

Design outcomes

Primary

MeasureTime frame
All-cause mortality

Secondary

MeasureTime frame
Cause of mortality (e.g., cardiovascular death, renal death, infectious death, cancer-related death, and others)

Countries

Japan

Contacts

Public ContactMasahiro Eriguchi

Nara medical university hospital Department of nephrology

meriguci@naramed-u.ac.jp0744-22-3051

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026