Association between Intraoperative Low PSI Exposure During Desflurane Anesthesia and Postoperative Cognitive Changes: A Prospective Observational Study

Association between Intraoperative Low Patient State Index (PSI) Exposure During Desflurane Anesthesia and Postoperative Cognitive Changes Assessed by Montreal Cognitive Assessment: A Single-Center Prospective Observational Study - DesPSI-MoCA Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000061068

Enrollment

180

Registered

2026-04-01

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients aged 60 years or older undergoing general anesthesia with desflurane

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged 60 years or older; elective surgery under general anesthesia maintained primarily with desflurane; expected surgical duration >=120 minutes; able to complete MoCA-J preoperatively and at POD7; written informed consent obtained

Exclusion criteria

Exclusion criteria: Known severe dementia or inability to perform MoCA-J (aphasia, visual or hearing impairment); emergency surgery; intracranial or cardiac surgery (cardiopulmonary bypass); cases in which maintenance anesthesia was switched primarily to TIVA; cases in which MoCA-J could not be administered within the specified postoperative period; poorly controlled asthma

Design outcomes

Primary

Measure	Time frame
Change in MoCA (MoCA score at postoperative day 7 minus preoperative MoCA score)	—

Secondary

Measure	Time frame
Incidence of clinically meaningful MoCA decline (>=2 points); MoCA subscale scores; incidence of postoperative delirium (POD); delirium duration; QoR-15J (POD2 and POD7)	—

Countries

Japan

Contacts

Public ContactYamato Tamakawa

Hitachi General Hospital, Department of Anesthesiology Department of Anesthesiology

tamayama66433@gmail.com08066433621

Outcome results