The trail aims to enrol 300 patients and follow them for 60 days. Eligible patients must have significant cardiovascular risk factors, be aged 45 years or older, and be scheduled for elective surgery under general anaesthesia with an anticipated duration of 1hour or more.
Conditions
Interventions
In the stellate ganglion block (SGB) arm, patients will be assigned to receive the right SGB under ultrasound guidance. Patients will lie supine with a slightly extended neck, and a high frequency ult
s syndrome. Additionally, monitoring facial temperature and index finger perfusion index will serve as adjunctive measures to confirm successful blockade.
Patients in the control arm received an equal
Sponsors
Department of Anaesthesiology, People's Hospital of Chongqing Banan District
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1, Patients aged 45 years or older, scheduled for elective laparoscopic or open major surgery under general anesthesia, with an expected operative duration of 1 hour or more and an anticipated hospital stay of 3 days or longer. 2, At least three of the following risk factors: age over 65 years; history of peripheral artery disease; history of ischemic heart disease; history of congestive heart failure; history of stroke or transient ischaemic attack; serum creatinine >2.0 mg/dL; diabetes requiring medication; hypertension requiring medication; current smoking or smoking cessation for less than 2 years.
Exclusion criteria
Exclusion criteria: 1, Coagulation disorders. 2, Localised skin infection. 3, Glaucoma. 4, Thyroid disorders. 5, Cardiac conduction abnormalities. 6, Patients with psychiatric disorders unable to cooperate. 7, Pregnant women. 8, Allergy to investigational drugs used in the trial. 9, Septicaemia. 10, Preoperative treatment with positive inotropic agents. 11, Severe heart failure (defined as ejection fraction <30%). 12, Acute cardiac conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the incidence of myocardial injury, defined as any myocardial infarction or any elevated troponin I level (exceeding the upper reference limit), deemed to be attributable to myocardial ischaemia, occurring within the first 30 days after the initiation of surgery. | — |
Countries
Asia(except Japan)
Contacts
Public ContactJie Chen
People's Hospital of Chongqing Banan District Department of Anaesthesiology
Outcome results
None listed