A Study on the Effects of TERUPLUG on Postoperative Bleeding and Alveolar Socket Wound Healing Following Extraction of Impacted Mandibular Third Molars

A Study on the Effects Of Collagen-Based Absorbable Topical Hemostatic Agent (TERUPLUG )on Postoperative Bleeding and Alveolar Socket Wound Healing Following Extraction of Impacted Mandibular Third Molars - THE Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000061025

Enrollment

200

Registered

2026-04-01

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Completely impacted mandibular third molar

Interventions

With Terplug insertion into the extraction socket Single intervention during extraction Without Terplug insertion into the extraction socket Single intervention during extraction

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing extraction of completely impacted mandibular third molars Postoperative use of antibiotics and analgesics is not restricted when used appropriately

Exclusion criteria

Exclusion criteria: Patients with diabetes or osteoporosis Patients taking antithrombotic drugs

Design outcomes

Primary

Measure	Time frame
Presence of abnormal pain after tooth extraction Presence of infection after tooth extraction Intensity of postoperative pain Presence of bleeding after tooth extraction	—

Secondary

Measure	Time frame
Modified Healing Index (MHI) and pain score Attachment loss in the distal central region of the second molar Changes in soft tissue contour in the horizontal and vertical directions	—

Countries

Japan

Contacts

Public ContactHIROSHI IWABUCHI

International University of Health and Welfare Hospital Dentistry & Oral Surgery

hiwabuchi@ihwg.jp+81-0287-39-3060

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026