Patients undergoing colonoscopy (for screening or diagnostic purposes)
Conditions
Interventions
None listed
Sponsors
Sendai City Medical Center Sendai Open Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Aged 20 years or older with opt-out consent obtained Underwent colonoscopy for screening or diagnostic purposes with RMZ as the sedative Had a colonoscopy under PRO monotherapy (opioid-free) at our institution within the past 2 years, completed by a single operator with a single scope to cecal intubation Procedures performed by an expert endoscopist (board-certified gastroenterologist with >=2,000 colonoscopy experience) in both prior and current examinations
Exclusion criteria
Exclusion criteria: Change in ASA PS classification between prior and current examinations History of colorectal surgery (except appendectomy) Emergency endoscopy Cases where procedural difficulty, invasiveness, or examination time was judged significantly different between prior and current examinations (e.g., therapeutic endoscopy such as ESD/EMR, severe adhesions, strictures) Cold snare polypectomy for <=4 lesions is NOT excluded Pregnant or possibly pregnant Currently receiving opioids (including tramadol) Judged inappropriate by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose weight ratio (weight-adjusted total dose) For each patient, the ratio of weight-adjusted doses calculated using the following formula (median and correlation coefficient): Dose Weight Ratio (mg/kg) = Total Dose (mg) / Weight (kg) Comparison of RMZ and PRO to derive the RMZ-to-PRO conversion ratio. | — |
Countries
Japan
Contacts
Public ContactTakeshi Shimizu
Sendai City Medical Center Sendai Open Hospital Department of Gastroenterology
Outcome results
None listed