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Effects of Bathing with Carbon Dioxide Bath Additives on Dry Eye Symptoms and Eye Strain

Verification of the Effects of Bathing and Carbon Dioxide Bathing on Eye Strain and Dry Eye - Study on Dry Eye via Bathing and CO2 Bathing

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000060945
Enrollment
10
Registered
2026-03-16
Start date
2025-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye, Eye strain

Interventions

Carbonated bath: Whole-body bathing for 15 minutes in 39 degrees Celsius water containing inorganic salt-containing carbon dioxide bath additives. Single intervention. Warm water bath (Control): Whole

Sponsors

Earth Corporation
Lead Sponsor
Lid and Meibomian Gland Working Group (LIME), Itoh Clinic
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 to 59 years. 2. Participants with chronic dry eye symptoms (J-OSDI score >= 13). 3. Participants without a regular bathing habit (bathing in a tub < 4 times per week). 4. Participants who understand the study and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Participants currently receiving treatment for ocular diseases (e.g., infections, severe corneal disorders). 2. Participants with serious systemic diseases (e.g., severe heart disease, skin disease). 3. Pregnant or lactating women. 4. Others deemed inappropriate by the principal investigator.

Design outcomes

Primary

MeasureTime frame
Change in eyelid blood flow before and after intervention (measured by laser speckle blood flow imager). Time points: After rest/acclimatization and 12 minutes after bathing.—

Secondary

MeasureTime frame
Tear dynamics: Changes in tear meniscus height (TMH) and tear film break-up time (BUT). Meibomian gland function: Changes in the meibomian gland plugging score. Subjective symptoms: Changes in eye strain, dryness, and neck stiffness evaluated by Visual Analogue Scale (VAS). (All measures assessed after acclimatization and 12 minutes after bathing.)—

Countries

Japan

Contacts

Public ContactGenki Hata

Earth Corporation Tsukuba Research Center

hata-genki@earth.jp08067255003

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026