Investigation of Humoral Factors in the Pathogenesis of Acquired Kidney Diseases

Investigation of Humoral Factors in the Pathogenesis of Acquired Kidney Diseases - HFAK Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060935

Enrollment

1083

Registered

2026-04-01

Start date

2026-02-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic nephrotic syndrome, IgA nephropathy, membranous nephropathy, focal segmental glomerulosclerosis, lupus nephritis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study will include patients diagnosed with idiopathic nephrotic syndrome or other acquired kidney diseases who have stored serum samples, as well as patients or healthy volunteers who provide written informed consent to participate in the prospective cohort study.

Exclusion criteria

Exclusion criteria: Participants who do not provide consent for participation in the study, or who have evidence of infection such as fever, will be excluded.

Design outcomes

Primary

Measure	Time frame
Serum anti-Crb2 antibody titers in patients with idiopathic nephrotic syndrome at onset and relapse	—

Secondary

Measure	Time frame
1. Correlation between anti-Crb2 antibody titers and proteinuria 2. Association between anti-Crb2 antibody titers and disease activity 3. Association between serum anti-nephrin antibody titers, serum anti-sialic acid antibody titers, circulating chemokine levels, and serum anti-Crb2 antibody titers	—

Countries

Japan

Contacts

Public ContactZentaro Kiuchi

Kyorin University School of Medicine Department of Pediatrics

zenkiuchi@ks.kyorin-u.ac.jp0422-47-5511

Outcome results