healthy adults
Conditions
Interventions
None listed
Sponsors
Pias Corporation
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Japanese females aged 45 to 55 years old at the time of informed consent 2) Those who can consent to undergoing tape stripping, applying and removing tape to the skin 20 times on the same location on the inner upper arm
Exclusion criteria
Exclusion criteria: 1) Those suspected of having, or with a history of, severe digestive, liver, kidney, cardiovascular, blood, or endocrine disorders, or malignant neoplasms 2) Those with extremely irregular eating habits 3) Those with a history of alcohol or drug dependence 4) Those who consume excessive amounts of alcohol (exceeding 20g/day) six or more days per week 5) Those with chronic inflammation (e.g., diabetes, liver disease, autoimmune disorders), kidney disease, digestive disorders, heart disease, respiratory disease, peripheral vascular disease, or other serious underlying conditions 6) Those currently undergoing treatment for any disease 7) Those currently taking medications (including over-the-counter products) or supplements with estrogenic effects 8) Those currently participating in another clinical trial, or who participated within the past month 9) Those who wish to become pregnant during the trial, are pregnant (including those who may be pregnant), or are breastfeeding 10) Those with current allergic skin conditions such as atopic dermatitis 11) Those who have experienced allergic reactions to food or cosmetics 12) Those who have undergone cosmetic medical procedures or special skincare treatments (e.g., peeling, hair removal) within 4 weeks prior to the trial start date, or plan to undergo such procedures during the trial period 13) Those who have been exposed to ultraviolet rays beyond normal daily activities (e.g., prolonged outdoor work, exercise, swimming, leisure activities) within 4 weeks prior to the trial start date, or who plan to do so during the trial period 14) Those with irregular daily rhythms, such as night shift workers or those on rotating day-night shifts 15) Those who smoke an average of 21 or more cigarettes per day 16) Those who engage in strenuous sports or are currently dieting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. blood test (Hematological tests, estradiol, follicle-stimulating hormone(FSH), progesterone, anti-Mullerian hormone(AMH),IL-6,CRP,TNF-alpha,total antioxidant capacity(PAO), pentosidine) 2. skin pH 6. analysis of horny cell layer 7. questionnaire | — |
Countries
Japan
Contacts
Public ContactMiwa Kaneko
SOUKEN Co., Ltd Management Division
Outcome results
None listed