Association Between Perioperative Serum Creatinine Changes and Short- and Mid-to-Long-Term Renal Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation: A Retrospective Observational Study

Association Between Perioperative Serum Creatinine Changes and Short- and Mid-to-Long-Term Renal Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation: A Retrospective Observational Study - Association Between Perioperative Serum Creatinine Changes and Short- and Mid-to-Long-Term Renal Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation: A Retrospective Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000060903

Enrollment

500

Registered

2026-03-12

Start date

2026-02-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with aortic stenosis, with or without heart failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients with aortic stenosis, with or without heart failure

Exclusion criteria

Exclusion criteria: CRRT

Design outcomes

Primary

Measure	Time frame
Primary outcomes Decline in eGFR at 2 weeks and 1 month postoperatively Relative change from preoperative baseline eGFR decline 10% or 20% Secondary outcomes: Decline in eGFR at 6 months, 1 year, and 3 years postoperatively Progression of CKD stage Association with AKI diagnosed according to KDIGO criteria Evaluation of the perioperative serum creatinine change period affecting mid- to long-term renal function Identification of intraoperative hemodynamic parameters (MAP, CVP) and clinically actionable cutoff values for intervention evaluating time-weighted exposure to hypotension (MAP <65 mmHg) and elevated CVP	—

Measure

Time frame

Primary outcomes Decline in eGFR at 2 weeks and 1 month postoperatively Relative change from preoperative baseline eGFR decline 10% or 20% Secondary outcomes: Decline in eGFR at 6 months, 1 year, and 3 years postoperatively Progression of CKD stage Association with AKI diagnosed according to KDIGO criteria Evaluation of the perioperative serum creatinine change period affecting mid- to long-term renal function Identification of intraoperative hemodynamic parameters (MAP, CVP) and clinically actionable cutoff values for intervention evaluating time-weighted exposure to hypotension (MAP <65 mmHg) and elevated CVP

—

Countries

Japan

Contacts

Public ContactYumi Obata

St. marianna university school of medicine Anesthesiology

y2obata@marianna-u.ac.jp0453661111

Outcome results