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Effects of Menstrual Cycle-Related Sex Hormone Fluctuations on Joint Laxity and Structural Properties

Effects of Menstrual Cycle-Related Sex Hormone Fluctuations on Joint Laxity and Structural Properties - Effects of Menstrual Cycle-Related Sex Hormone Fluctuations on Joint Laxity and Structural Properties

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000060901
Enrollment
60
Registered
2026-03-11
Start date
2026-01-16
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adult women

Interventions

To evaluate menstrual cycle-related variations, joint stability, and sex hormone concentrations, assessments will be conducted at two time points: the early follicular phase and the ovulatory phase. J

Sponsors

Niigata University of Health and Welfare
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: women with normal menstrual cycles

Exclusion criteria

Exclusion criteria: women with menstrual irregularities or amenorrhea

Design outcomes

Primary

MeasureTime frame
Sixty healthy adult women will be recruited as participants. For 1 month prior to the start of the experiment, participants will be asked to monitor their menstrual cycles by recording their basal body temperature each morning, identifying the day of ovulation using an ovulation predictor kit, and documenting the duration of menstruation. To evaluate menstrual cycle-related variations, joint stability, and sex hormone concentrations will be assessed at two time points: the early follicular phase and the ovulatory phase. Joint stability will be evaluated using an ultrasound imaging system in accordance with previous studies. For both the elbow joint and the foot, joint space distance will be measured under standardized mechanical loading conditions using a dedicated stress loading device. In addition, saliva samples will be collected using saliva collection kits, and salivary concentrations of sex hormones (estradiol and progesterone) will be analyzed. Foot morphology, including the hallux valgus angle, fifth toe varus angle, and medial longitudinal arch height, will be measured using a three-dimensional automatic foot scanner under two loading conditions (weight-bearing [seated and standing] and non-weight-bearing). Furthermore, the carrying angle of the elbow joint will be measured using a goniometer. These alignment measurements will be performed only once.

Countries

Japan

Contacts

Public ContactMutsuaki Edama

Niigata University of Health and Welfare Depeartment of physical therapy

edama@nuhw.ac.jp09071547408

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026