Patients undergoing autologous blood donation prior to orthognathic surgery
Conditions
Interventions
Autologous blood donation (400 mL), performed as part of routine clinical care, will be utilized as a controlled model of acute blood loss. The following additional assessments will be conducted for r
Sponsors
Nihon University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 18 to 65 years Scheduled for orthognathic surgery under general anesthesia Planned preoperative autologous blood donation (up to 800 mL) ASA physical status 1 to 2 Written informed consent obtained
Exclusion criteria
Exclusion criteria: Severe cardiovascular disease (arrhythmia, heart failure, ischemic heart disease) Anemia (Hb < 11.0 g/dL) Coagulation disorders or ongoing anticoagulant therapy Severe hepatic or renal dysfunction Regular use of medications affecting autonomic nervous function Pregnancy or breastfeeding Any condition deemed inappropriate by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in estimated continuous cardiac output (esCCO) before donation, immediately after donation, and after fluid replacement during autologous blood donation (400 mL) | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in estimated stroke volume (esSV), perfusion index (PI), non-invasive arterial pressure and arterial waveform parameters, hemoglobin level, and hematocrit level measured at three time points (before donation, immediately after donation, and after fluid replacement) | — |
Countries
Japan
Contacts
Public ContactKeisuke Kaneko
Nihon University School of Dentistry Department of Anesthesiology
Outcome results
None listed